Anti-Hu CD172ab APC Mab(SE5A5)
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| Product code: | 30-2890 |
|---|---|
| Clone name : | SE5A5 |
| Application : | FACS |
|---|---|
| Reactivity : | Human |
| Conjugate : | APC |
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| Amount | 100 Tests |
|---|---|
| Isotype | Mouse IgG1 |
| Purification | Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Content | Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Alternative Name | PTPNS1, BIT, MFR, SIRPA, SHPS1, SIRPB1, |
| Alternative Name | PTPNS1, BIT, MFR, SIRPA, SHPS1, SIRPB1, |
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Specificity: The mouse monoclonal antibody SE5A5 recognizes a common extracellular epitope on human CD172a and CD172b antigens (approx. 90 kDa and approx. 50 kDa, respectively), although its reactivity with CD172a is higher.
CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase substrate-1 (SHPS1), is a 75-110 kDa transmembrane glycoprotein expressed mainly on granulocytes, monocytes, macrophages, dendritic cells and neurons. Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation it recruits SH2 domain-containing tyrosine phosphatases, thereby regulating signal transduction processes related to cell activation, transmigration and phagocytosis. CD172a is a specific marker of cardiomyocytes derived from human pluripotent stem cells and serves as a negative regulator of signaling and growth in myeloid progenitor cells. Extracellular part of CD172b is 90% identical to that of CD172a, but unlike CD172, it has dramatically reduced intracellular domain.
Application Note:
Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
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