Monoclonal Antibody to Calponin-1 (Smooth Muscle Marker)(Clone : CNN1/832 + CALP)
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| Product code: | 36-1064 |
|---|---|
| Clone name : | CNN1/832 + CALP |
| Clonality : | Monoclonal |
| Application : | IHC, FACS, IF |
|---|---|
| Reactivity : | Human |
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| Isotype | Mouse IgG1, kappa |
|---|---|
| Purification | Affinity Chromatography |
| Content | 100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | CNN1 |
| Gene | CNN1 |
|---|---|
| Gene ID | 1264 |
| Uniprot ID | P51911 |
| Alternative Name | CNN1 |
Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist; a 34kDa form and a 29kDa form. Expression of the 29kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this MAb reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.
Application Note:
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 7.5-8.5, for 45 min at 95°C f
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