Monoclonal Antibody to SUMO-1(Clone : SM1/495)
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$499.00
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| Product code: | 36-1785 |
|---|---|
| Clone name : | SM1/495 |
| Clonality : | Monoclonal |
| Application : | IHC, FACS, WB, IF |
|---|---|
| Reactivity : | Human |
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| Isotype | Mouse IgG1, kappa |
|---|---|
| Purification | Affinity Chromatography |
| Content | 100 μg in 500 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | SUMO1||SMT3C||SMT3H3||UBL1||OK/SW-cl.43 |
| Gene | SUMO1 |
|---|---|
| Gene ID | 7341 |
| Uniprot ID | P63165 |
| Alternative Name | SUMO1||SMT3C||SMT3H3||UBL1||OK/SW-cl.43 |
This MAb is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane.
Application Note:
Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Western Blot (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM E
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