Phospho-Histone H2A.X (Ser139) (Clone: 1E4) rabbit mAb
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$428.00
In stock
| Product code: | 12-4115 |
|---|---|
| Clone name : | HisH2AXS139-1E4 |
| Clonality : | Monoclonal |
| Application : | FACS, WB |
|---|---|
| Reactivity : | Human |
| Conjugate : | Unconjugated |
Shipping Info:
For estimated delivery dates, please contact us at support@abeomics.com
| Amount | 200 l μl |
|---|---|
| Isotype | Rabbit IgG1k |
| Content | 1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA |
| Storage condition | Store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | H2AFX, H2AX, ?H2AX, gamma-H2AX |
| Alternative Name | H2AFX, H2AX, ?H2AX, gamma-H2AX |
|---|
Histone H2AX is a variant of the nucleosome core histone H2A and is phosphorylated at Ser139 in response to DNA damage. Histone H2AX phosphorylation is considered a specific reporter of double-strand DNA breaks. The protein is also referred to as gH2AX when phosphorylated at Ser139. H2AX phosphorylation is especially strong in response to double-strand breaks formed during apoptosis. However, physiological phosphorylation of Histone H2AX occurs when double-strand DNA breaks are formed during meiosis and V(D)J recombination. A549 and DU145 cell lines have been found to have higher expression levels of phosphorylated Histone H2AX compared to Jurkat, MCF-7, or HL-60 cell lines.
Application Note:
1μg/mL - 0.001μg/mL. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.(0.5mg/ml, more than 200 western blots)
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