Poly(I).Poly(C), HMW
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| Product code: | 15-1012 |
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| Application : | Functional Assay |
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| Amount | 1 mg |
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| Purification | Purity: >=99% |
| Content | liquid (1 mg/ml) |
| Storage condition | Store the product at 4°C for short term and at -20°C for long-term storage. The product is stable for 2 years at -20°C. |
| Alternative Name | Polyinosinic-polycytidylic acid, potassium salt (poly (I:C)) |
| Alternative Name | Polyinosinic-polycytidylic acid, potassium salt (poly (I:C)) |
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MW: High molecular weight (>1.5kb).
Formula: (C10H13N4O8P)x.(C9H14N3O8P)x_K
CAS#31852-29-6
Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-α and antiviral IFN-β, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
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