Polyclonal Antibody to DLC1 (Ab-868)
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| Product code: | 35-1866 |
|---|---|
| Clonality : | Polyclonal |
| Application : | WB |
|---|---|
| Reactivity : | Human |
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| Isotype | Rabbit IgG |
|---|---|
| Content | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | ARHGAP7|| KIAA1723|| STARD12 |
| Gene | DLC1 |
|---|---|
| Gene ID | 10395 |
| Uniprot ID | Q96QB1 |
| Alternative Name | ARHGAP7|| KIAA1723|| STARD12 |
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
Application Note:
Western blotting: 1:500~1:1000
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