Polyclonal Antibody to FNBP1
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$240.00
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| Product code: | 11-10022 |
|---|---|
| Clonality : | Polyclonal |
| Reactivity : | Human |
|---|
Shipping Info:
Order now and get it on Friday April 25, 2025
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| Amount | 100 μg |
|---|---|
| Isotype | Rabbit IgG |
| Purification | Protein A Chromatography |
| Content | 25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | FNBP1||FBP17||KIAA0554 |
| Gene | FNBP1 |
|---|---|
| Gene ID | 23048 |
| Uniprot ID | Q96RU3 |
| Alternative Name | FNBP1||FBP17||KIAA0554 |
| Immunogen Information | A partial length recombinant FNBP1 protein (amino acids 397-617) was used as the immunogen for this antibody. |
YWHAQ, also known as 14-3-3 tau (14-3-3tau) is a a phosphoserine-binding protein and a member of the 14-3-3 family of proteins. The 14-3-3 family members are dimeric phosphoserine/ phosphothreonine-binding proteins, which are involved in a very diverse spectrum of signaling pathways. YWHAQ plays a critical role in the regulation of E2F1 stability. It binds to Ser31-phosphorylated E2F1 and inhibits the ubiquitination of E2F1 during DNA damage. The binding of YWHAQ to E2F1 interferes with the function of an E31 ligase and therefore inhibits the ubiquitination and degradation of E2F1. This interaction is required for the expression and induction of several E2F1 apoptotic target genes as well as apoptosis during DNA damage.
Application Note:
Western blot analysis: 2-4 μg/ml
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