Polyclonal Antibody to HDAC3
As low as
$374.00
In stock
| Product code: | 35-1828 |
|---|---|
| Clonality : | Polyclonal |
| Application : | WB |
|---|---|
| Reactivity : | Rat, Mouse, Human |
Shipping Info:
For estimated delivery dates, please contact us at support@abeomics.com
| Isotype | Rabbit IgG |
|---|---|
| Content | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | HD3|| RPD3|| RPD3-2 |
| Gene | HDAC3 |
|---|---|
| Gene ID | 8841 |
| Uniprot ID | O15379 |
| Alternative Name | HD3|| RPD3|| RPD3-2 |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation Wei L.-N., Hu X., Chandra D., Seto E., Farooqui M.J. Biol.Chem. 275:40782-40787(2000) Li H., Leo C., Zhu J., Wu X., O'Neil J., Park E.-J., Chen J.D.Mol. Cell. Biol. 20:1784-1796(2000)
Application Note:
Predicted MW: 49kd, Western blotting: 1:500~1:1000
Write Your Own Review