Polyclonal Antibody to Histone H2A.X (Phospho-Ser139)
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| Product code: | 35-1247 |
|---|---|
| Clonality : | Polyclonal |
| Application : | WB, IF |
|---|---|
| Reactivity : | Human |
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| Isotype | Rabbit IgG |
|---|---|
| Content | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | H2A.X|| H2AFX|| H2a/x|| HIST5-2AX |
| Gene | H2AFX |
|---|---|
| Gene ID | 3014 |
| Uniprot ID | P16104 |
| Alternative Name | H2A.X|| H2AFX|| H2a/x|| HIST5-2AX |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Yaneva M, et al. (2005) Nucleic Acids Res. 33(16): 5320-5330.
Tsukuda T, et al.(2006) Nature. Author manuscript; available in PMC 2006 March 6.
Application Note:
Predicted MW: 15kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200
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