Polyclonal Antibody to MSK1 (Ab-376)
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$374.00
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| Product code: | 35-1536 |
|---|---|
| Clonality : | Polyclonal |
| Application : | WB |
|---|---|
| Reactivity : | Human |
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| Isotype | Rabbit IgG |
|---|---|
| Content | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | MSPK1|| RPS6KA5 |
| Gene | RPS6KA5 |
|---|---|
| Gene ID | 9252 |
| Uniprot ID | O75582 |
| Alternative Name | MSPK1|| RPS6KA5 |
Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
Application Note:
Predicted MW: 90kd, Western blotting: 1:500~1:1000
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