Polyclonal Antibody to PKC Theta (Ab-695)
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$374.00
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| Product code: | 35-1524 |
|---|---|
| Clonality : | Polyclonal |
| Application : | IHC, WB |
|---|---|
| Reactivity : | Human |
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| Isotype | Rabbit IgG |
|---|---|
| Content | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
| Alternative Name | KPCT|| PKC-theta|| PKCQ|| PRKCQ|| PRKCT |
| Gene | PRKCQ |
|---|---|
| Gene ID | 5588 |
| Uniprot ID | Q04759 |
| Alternative Name | KPCT|| PKC-theta|| PKCQ|| PRKCQ|| PRKCT |
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Application Note:
Predicted MW: 80kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
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