STAT3 Leeporter™ Luciferase Reporter-HEK293 Cell Line
As low as
$4,500.00
In stock
| Product code: | 14-114ACL |
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| Application : | Functional Assay |
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Shipping Info:
Order now and get it on Tuesday April 29, 2025
Same day delivery FREE on San Diego area orders placed by 1.00 PM
| Amount | 1 Vial |
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| Content | Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
| Storage condition | Immediately upon receipt, store in liquid nitrogen. |
The STAT3 Leeporterâ„¢ Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter under the transcriptional control of the STAT3 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT3. As a transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) is activated through phosphorylation at tyrosine 705 in response to various cytokines including IL-6, interferons, epidermal growth factor, hepatocyte growth factor and leukemia inhibitory factor. The phosphorylated STAT3 forms homodimers or heterodimers with STAT1, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT3 induction by IL-6 as well as Oncostatin-M is shown in Figures 1 and 3.
Application Note:
Application:
Monitor the STAT3 signaling pathway activity.
Screen for activators or inhibitors of the STAT3 signaling pathway.
Culture conditions:
Cells should be grown at 37oC with 5% CO2 using DMEM medium (w/ L-Glutamine, 4.5g/L Glucose a
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